An Elasticity Microscope. Part II: Experimental Results

N. Abraham Cohn, Stanislav Y. Emelianov, and Matthew O'Donnell

ABSTRACT Initial experimental results from a 50 MHz elasticity microscope are shown. Using methods discussed previously, we present measured displacement and normal axial strain fields from a tissue mimicking phantom. Results from this homogenous gel are compared to a finite element simulation of the deformation experiment. The spatial resolution is estimated to be approximately 52 µm for axial displacements, and 71 µ for normal axial strains. These estimates were further tested by imaging a phantom containing a hard cylindrical inclusion with cross-sectional diameter of 265 µm. By examining the strain transition between regions in this image, the spatial resolution of the normal axial strain was verified to be at most 88 µm. A typical experiment produces peak normal axial strain around 3%. These experiments demonstrate the potential of high frequency ultrasound as a means for elasticity microscopy. Preliminary deformation experiments are presented on porcine epidermis.

1997 IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 44:1320-1331

© 1997 by The Institute of Electrical and Electronics Engineers, Inc. All rights reserved.

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